I heard some interesting information about Nickel wire, that it is potentially not as safe as we may have been led to believe. Titanium is also not without its own potential hazards, if heated high enough it can potentially turn into harmful oxides, although under normal vaping conditions this should not occur. These are the 2 main types of wire in use for Temperature Control, I am sure there are vapers experimenting with other types of wire & Titanium itself is not widely used, Nickel is most likely used in over 95% of TC set ups. While there are some potential risks, I don't think there is any need for panic or alarm at this stage. However, knowing the risks is never a bad thing & you can decide for yourself if TC is for you or not, just as you can decide for yourself whether to use flavorings or not (which are still potentially more of a risk). The idea of this thread is to inform & to discuss the pros & cons of the wires used in TC. This does however beg the question, how safe is Ni200 wire when used in a vaping device? From what I remember of what I heard, the concern is that Nickel may be being leached into juice & vaporised, then inhaled when vaping. If that is the case, then aerosol-ed metal particles are entering our lungs, our lungs were not designed to handle metal particles very well, this is where the concern is. At this stage, it is more speculation than fact, which is based upon the premise that if you can taste a metallic taste, then there is likely metal in the aerosol. If we go back in time a few years, there was debate about Nichrome & Kanthal, as the best choice for resistance wire, back then Kanthal was new, Nichrome was the common metal used in pre-made coils. Rebuilders, mainly chose Kanthal because it was "cleaner tasting", this is due to the same metal in Nichrome as in Ni200 - Nickel. Many vapers, including myself, can taste the Nickel in Nichrome, when used in vaping. Many are also saying they can taste the Nickel in Ni200 TC builds/devices. Further research needs to be done, to determine if this is actually the case & if so at what levels Nickel metal is in the aerosol(s). Titanium's problem seems to be more about dry burning or when making the coil initially & "glowing" the coil to help it form. When heating Titanium above a certain temperature, it is possible to create carcinogenic oxides. There is another potential issue with Titanium, that it can spontaneously combust, if heated too high. Both of these issues have a lot to do with the grade of titanium being used, from what I understand. Grade 1 Titanium, has a very low oxygen "impurity" inclusion, making it harder for it to form oxides of the type we want to avoid, it also makes it nearly impossible to make it instantaneously combust, in our applications. However under normal vaping conditions, provided there is none of the oxides already present, Titanium would seem to be the safer alternative. Our bodies handle Titanium much better than they do Nickel & it is believed there is a lower chance for Titanium to hitch a ride on the vapor we inhale. So there are potential risks with both wire types but until more research is done, we won't know just how much risk is involved. What we do know is that a Dry Hit from a non -TC build is very unpleasant & this is due in part to formaldehyde & carbon monoxide, both of which are potentially more harmful than the risks associated with using either of these wires. I still believe Temperature Control is a step forward for vaping & is lowering the risks overall, still it is not without its potential drawbacks. I do not claim to be an expert in the hazards of wire choice/use, so if any of the above info/speculation is incorrect please correct it.